Table 1.
Morphometric analysis of ECs apoptosis, proliferation and microvessel density in the lungs of KDITSN mouse. The number of lung microvessels labeled by AQP-1 and GS-1 lectin was normalized per 30,000 μm2 surface area
| Label/time point | Ctrl. | 72 h | 10d | 24d |
|---|---|---|---|---|
| TUNEL + ECs/25 medium-sized vessels | 48.0 ± 2.4 | 115 ± 2.9 | 165 ± 2.8 | 25 ± 2.0 |
| AQP-1 microvessels, Ø < 9 μm | 38.8 ± 4.0 | 28.81 ± 2.4 | 25.6 ± 4.0 | ND |
| BrdU + ECs/25 medium-sized vessels | 83.0 ± 5.0 | ND | 154 ± 3.8 | 173 ± 5.6 |
| BrdU (1.5 × 102 μm alveolar wall length) | 4.4 ± 1.0 | ND | 8.3 ± 1.5 | 9.4 ± 1.8 |
| GS-1 lectin(microvessels, Ø < 20 μm) | 365 ± 9.0 | 270 ± 4.5 | ND | 443 ± 7.1 |