Fig. 1.
Lung function and survival in chlorine-exposed FVB/NJ mice. Mice were exposed to chlorine, and respiratory system resistance (Rrs) at baseline and in response to inhaled methacholine was analyzed at multiple times after exposure. One group of unexposed mice was measured; the same data were plotted in each graph for ease of comparison with exposed mice. Values are means ± SE (n = 3–6 mice per group); methacholine dose-response curves were significantly different (P < 0.05) between chlorine-exposed and unexposed mice at each time point. Lethality data are shown as the percentage of remaining animals that died during each time period.