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Metformin does not alter the expression of angiogenic factors in IPH-PAEC. The expression of vascular endothelial growth factor (VEGF, P < 0.05, n = 4) and platelet-derived growth factor-β (PDGF-β, P < 0.05, n = 4) were decreased in IPH-PAEC compared with control PAEC (A). The expression of VEGF (B) and PDGF-β (C) were not changed after Metformin treatment for either 24 h or 48 h. *P < 0.05 compared with control PAEC.
