Fig. 8.

A: representative immunohistochemical staining of neutrophil in kidney sections from WT and TRPV1^−/− mice (a and b) and LPS (3 mg/kg ip)-treated WT and TRPV1^−/− mice with (e and f) or without (c and d) capsazepine (CAPZ, 3 mg/kg ip) treatment. Tissue samples were collected at 6 h after LPS treatment. Magnification, ×400. B: bar graph shows the number of renal cortical neutrophil expressed as cells per square millimeter. C: responses of serum TNF-α to bolus injection of LPS (3 mg/kg ip) in WT and TRPV1^−/− mice with or without CAPZ treatment. Serum samples were collected at 6 h after LPS treatment. Values are means ± SE (n = 7 to 8). *P < 0.05 compared with control WT or TRPV1^−/− mice; †P < 0.05 compared with LPS-treated WT mice.