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Effect of TNF-α administration on MAP and plasma sFlt-1 levels in NP rats. MAP increased in response to TNF-α infusion (50 ng/day for 5 days) into NP rats (A). Plasma levels of sFlt-1 increased significantly in TNF-α-induced hypertensive pregnant rats compared with NP rats (P < 0.05) (B). Data were analyzed by an unpaired t-test and are shown as means ± SE.
