Renal damage scores in ANG II-infused rats. A: damage in interstitial arteries was exacerbated in male MatSep rats compared with control rats in response to ANG II infusion. B: renal damage in response to ANG II was similar in control and female MatSep rats. Lower panel pictures show representative pictures of glomerulus in male control (C) and MatSep (D) and female control (E), and MatSep (F) rats; interstitial artery in male control (G) and MatSep (H) and female control (I) and MatSep (J) rats. *P < 0.05. TI, tubulointerstitium; IA, interstitial arteries; G, glomerulus; GA, glomerular arteriolae. Score: 0, nil; 1, mild; 2 moderate; 3 severe. Scale bar = 25 μM.