Table 1.

Effect of hE-Hb-B10 on the hemolytic rate in SS and HS mice

	Whole Blood Hb, g/dl	Reticulocyte Count, percentage of red blood cells	Plasma Lactate Dehydrogenase Activity, IU/l
SS mice
PBS	7.0 ± 0.7 (n = 9)	53 ± 14 (n = 9)	211 ± 48 (n = 9)
hE-Hb-B10	6.3 ± 0.9 (n = 7)	55 ± 12 (n = 7)	173 ± 42 (n = 7)
HS mice
PBS	5.3 ± 0.7 (n = 14)	94 ± 3 (n = 7)	860 ± 173 (n = 13)
hE-Hb-B10	4.7 ± 0.8 (n = 11)	93 ± 4 (n = 11)	963 ± 256 (n = 12)

Values are means ± SD; n, no. of mice/group. SS mice, mice with sickle cell disease; HS mice, mice with hereditary spherocytosis.