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Effect of l-NAME on ATRA-induced increase in cGMP levels in mesenteric arterial rings with intact or denuded endothelium. Mesenteric arterial rings with or without endothelium were incubated with ATRA (10−6 M) in the presence or absence of l-NAME (10−4 M), an NOS inhibitor. Each value represents the mean ± SE. *P < 0.01 vs. control (Endo+, ATRA−, and l-NAME−). #P < 0.01 vs. ATRA group (Endo+, ATRA+, and l-NAME−); n = 6.
