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Effect of l-NAME and/or charybdotoxin (ChTX), a calcium-activated potassium channel blocker, on ATRA-induced relaxation in Phe-preconstricted mesenteric arterial rings. Phe-preconstricted mesenteric arterial rings were incubated with l-NAME (10−4 M) with or without ChTX (10−5 M) for 30 min and then treated with ATRA (1 × 10−8–3 × 10−6 M). Each value represents the mean ± SE. *P < 0.01, ATRA vs. other groups; n = 5.
