Fig. 7.

Concentration-response curves of retinoic acid receptor (RAR) and retinoic X receptor (RXR) agonists on Phe-preconstricted endothelium-intact mesenteric arterial rings. Phe-preconstricted mesenteric arterial rings were incubated with CH55 (10⁻⁸–3 × 10⁻⁶ M, n = 6), an RAR agonist, or LGD1069 (10⁻⁸–3 × 10⁻⁶ M, n = 7), an RXR agonist (n = 8 for ATRA alone) (A) or the combination of CH55 and LGD1069 (n = 4) (B) for 1 min. Each value represents the mean ± SE. *P < 0.05, DMSO (vehicle) vs. other group.