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Concentration-response curves of RAR and RXR antagonists on the ATRA-induced vasorelaxation in Phe-preconstricted mesenteric arterial rings. Phe-preconstricted mesenteric arterial rings were incubated with BMS493 (10−7 M), an RAR antagonist; UVI3003 (10−7 M), an RXR receptor antagonist; or the combination of BMS493 and UV13003 for 30 min and then incubated with ATRA. Each value represents the mean ± SE. *P < 0.01 vs. other groups; n = 8.
