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. 2012 Nov 29;12:239. doi: 10.1186/1472-6882-12-239

Table 2.

Impact of drug intervention on the animal daily behavior in CCl4-induced liver fibrotic rats (n = 7,x¯±s)

Index
Body weight (g)
Water drinking (mL per rat)
feeding (g per rat)
Group dose mg/kg n D0 D14 D35 D49 D0 D14 D35 D49 D0 D14 D35 D49
Normal

7
195 ± 6.1
303 ± 10.0
368 ± 41.2
416 ± 25.4
41.0 ± 1.4
60.0 ± 21.2
43.1 ± 11.5
61.4 ± 0.9
21.8 ± 2.0
37.6 ± 0.6
25.7 ± 0.2
23.8 ± 0.2
Model

7
198 ± 9.5
267 ± 40.3△△
288 ± 15.6△△
302 ± 17.2△△
36.7 ± 2.4
41.7 ± 9.4
35.0 ± 4.7
26.8 ± 2.5
18.1 ± 1.2
29.5 ± 2.4
20.2 ± 4.5
17.6 ± 7.4
Silymarin
150
7
192 ± 8.3
260 ± 40.4
293 ± 46.0
306 ± 55.1
47.0 ± 9.9
33.8 ± 5.3
27.5 ± 0.0
22.9 ± 7.7
21.7 ± 2.3
22.3 ± 9.8
17.3 ± 4.1
19.5 ± 5.0
Berberine
120
7
195 ± 5.3
277 ± 23.3
292 ± 33.4
309 ± 28.9
41.0 ± 1.4
37.5 ± 0.0
40.4 ± 4.1
34.3 ± 7.8
19.1 ± 2.9
25.3 ± 0.2
20.1 ± 1.1
19.5 ± 0.5
CRAE
600
7
195 ± 7.5
271 ± 24.6
300 ± 30.8
318 ± 35.7
34.0 ± 8.5
35.6 ± 2.7
34.4 ± 0.9
28.3 ± 4.7
16.1 ± 0.0
25.3 ± 3.3
17.8 ± 4.1
19.3 ± 1.2
Bear bile
200
7
201 ± 1.3
285 ± 21.4
321 ± 19.1
358 ± 40.7
33.0 ± 1.4
31.9 ± 9.7
36.3 ± 7.1
31.2 ± 3.5
19.0 ± 0.6
24.8 ± 3.7
22.5 ± 2.2
19.9 ± 0.3
TUDCA 20 7 194 ± 8.8 278 ± 18.1 296 ± 22.3 320 ± 28.2 41.5 ± 3.5 31.3 ± 8.8 37.1 ± 7.7 26.3 ± 8.8 16.2 ± 6.8 23.7 ± 0.3 15.3 ± 2.1 18.9 ± 2.8

p < 0.05 when compared with normal group; △△p < 0.01 when compared with normal group.