Table 2.
Index |
Body weight (g) |
Water drinking (mL per rat) |
feeding (g per rat) |
|||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Group | dose mg/kg | n | D0 | D14 | D35 | D49 | D0 | D14 | D35 | D49 | D0 | D14 | D35 | D49 |
Normal |
— |
7 |
195 ± 6.1 |
303 ± 10.0 |
368 ± 41.2 |
416 ± 25.4 |
41.0 ± 1.4 |
60.0 ± 21.2 |
43.1 ± 11.5 |
61.4 ± 0.9 |
21.8 ± 2.0 |
37.6 ± 0.6 |
25.7 ± 0.2 |
23.8 ± 0.2 |
Model |
— |
7 |
198 ± 9.5 |
267 ± 40.3△△ |
288 ± 15.6△△ |
302 ± 17.2△△ |
36.7 ± 2.4 |
41.7 ± 9.4 |
35.0 ± 4.7 |
26.8 ± 2.5△ |
18.1 ± 1.2 |
29.5 ± 2.4 |
20.2 ± 4.5 |
17.6 ± 7.4 |
Silymarin |
150 |
7 |
192 ± 8.3 |
260 ± 40.4 |
293 ± 46.0 |
306 ± 55.1 |
47.0 ± 9.9 |
33.8 ± 5.3 |
27.5 ± 0.0 |
22.9 ± 7.7 |
21.7 ± 2.3 |
22.3 ± 9.8 |
17.3 ± 4.1 |
19.5 ± 5.0 |
Berberine |
120 |
7 |
195 ± 5.3 |
277 ± 23.3 |
292 ± 33.4 |
309 ± 28.9 |
41.0 ± 1.4 |
37.5 ± 0.0 |
40.4 ± 4.1 |
34.3 ± 7.8 |
19.1 ± 2.9 |
25.3 ± 0.2 |
20.1 ± 1.1 |
19.5 ± 0.5 |
CRAE |
600 |
7 |
195 ± 7.5 |
271 ± 24.6 |
300 ± 30.8 |
318 ± 35.7 |
34.0 ± 8.5 |
35.6 ± 2.7 |
34.4 ± 0.9 |
28.3 ± 4.7 |
16.1 ± 0.0 |
25.3 ± 3.3 |
17.8 ± 4.1 |
19.3 ± 1.2 |
Bear bile |
200 |
7 |
201 ± 1.3 |
285 ± 21.4 |
321 ± 19.1 |
358 ± 40.7 |
33.0 ± 1.4 |
31.9 ± 9.7 |
36.3 ± 7.1 |
31.2 ± 3.5 |
19.0 ± 0.6 |
24.8 ± 3.7 |
22.5 ± 2.2 |
19.9 ± 0.3 |
TUDCA | 20 | 7 | 194 ± 8.8 | 278 ± 18.1 | 296 ± 22.3 | 320 ± 28.2 | 41.5 ± 3.5 | 31.3 ± 8.8 | 37.1 ± 7.7 | 26.3 ± 8.8 | 16.2 ± 6.8 | 23.7 ± 0.3 | 15.3 ± 2.1 | 18.9 ± 2.8 |
△p < 0.05 when compared with normal group; △△p < 0.01 when compared with normal group.