Table 3.

Impact of drug intervention on the animal daily behavior in bile duct ligation-induced liver fibrotic rats (n = 7,$\overline{x}\pm s$)

Index			Body weight (g)				Water drinking (mL per rat)				feeding (g per rat)
group	dose mg/kg	n	D0	D14	D21	D28	D0	D14	D21	D28	D0	D14	D21	D28
Normal	—	7	207 ± 12.0	328 ± 9.6	382 ± 12.1	389 ± 17.7	37.5 ± 0.0	56.9 ± 8.0	53.1 ± 2.7	51.3 ± 8.8	32.3 ± 11.1	31.1 ± 18.4	32.8 ± 2.4	33.8 ± 0.7
Sham	—	7	214 ± 5.4	321 ± 18.9	384 ± 26.2	389 ± 28.3	54.4 ± 6.2	60.0 ± 14.1	60.6 ± 4.4	62.5 ± 7.1	38.4 ± 0.7	34.0 ± 3.0	32.0 ± 0.0	27.1 ± 5.1
Model	—	7	213 ± 7.8	290 ± 16.2△△	332 ± 18.2△△	338 ± 26.0△△	41.3 ± 1.8	74.7 ± 1.9	54.0 ± 5.7	48.3 ± 11.8	8.7 ± 3.9△△	27.1 ± 1.6	27.7 ± 3.0	26.2 ± 1.9△△
Silymarin	150	7	210 ± 6.2	260 ± 24.4	289 ± 15.8	291 ± 15.2	57.4 ± 1.9	85.0 ± 49.5	72.3 ± 0.9*	59.3 ± 3.8*	8.3 ± 2.7	26.9 ± 4.6	22.9 ± 0.4	21.0 ± 0.6
Berberine	120	7	210 ± 6.2	294 ± 29.9	342 ± 31.0	340 ± 32.0	36.1 ± 0.2	76.3 ± 23.0	78.8 ± 3.1**	62.5 ± 7.1**	9.4 ± 1.0	25.7 ± 3.9	28.1 ± 1.9	28.9 ± 3.0
CRAE	600	7	208 ± 6.0	275 ± 25.2	320 ± 3.5	324 ± 2.4	55.0 ± 14.1	70.8 ± 8.2	75.8 ± 5.9**	61.3 ± 15.9*	7.8 ± 1.7	21.6 ± 11.0	28.6 ± 3.9	28.7 ± 1.3
Bear bile	200	7	207 ± 7.5	293 ± 38.5	331 ± 60.5	345 ± 64.7	34.4 ± 0.9	81.3 ± 1.8	75.6 ± 2.7**	72.5 ± 10.6**	8.2 ± 2.2	24.6 ± 1.2	28.2 ± 1.9	29.4 ± 0.8
TUDCA	20	7	212 ± 5.5	279 ± 30.1	311 ± 58.9	307 ± 72.5	30.1 ± 5.5	76.7 ± 28.3	78.3 ± 11.8**	63.3 ± 18.9*	6.9 ± 2.6	24.2 ± 1.3	26.3 ± 2.1	24.8 ± 4.6

^△p < 0.05 when compared with normal group; ^△△p < 0.01 when compared with normal group; ^*p < 0.05 when compared with model group; ^**p < 0.01 when compared with model group.