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Intravesical instillation of VEGF induces a time-dependent alteration in the density of TRPV1-positive sensory fibers in the urothelium and lamina propria (A) and detrusor and and adventitia (B) layers. Quantification of TRPV1-IR in the C57BL/6 urinary bladder isolated 1 week after: 1, 2, 4, and 6 weekly instillations of VEGF of PBS (N=8 per group). Asterisks indicate a statistically significant difference (p values < 0.05) when compared to the PBS group.
