. 2011 Nov 19;35(1):117–128. doi: 10.1007/s11357-011-9337-y

Table 3.

pD₂ values and maximal responses (Emax) to U46619 in aortic rings in the absence (Control) and in the presence of l-NAME (10⁻⁴ M), indomethacin (10⁻⁵ M) or l-NAME plus indomethacin from 3-, 6-, and 10-month-old of both SAMR1 and SAMP8 mice groups

	SAMR1		SAMP8
	pD₂	Emax	pD₂	Emax
Control
3 months	7.93 ± 0.04	1,224 ± 50	8.07 ± 0.04	1,435 ± 60*
6 months	7.92 ± 0.09	1,230 ± 60	8.24 ± 0.03^,*	1,581 ± 51^,*
10 months	8.13 ± 0.08^,*	1,400 ± 44^,*	8.30 ± 0.08^,*	1,893 ± 67^,^,**
l-NAME 10⁻⁴ M
3 months	8.27 ± 0.06****	1,496 ± 83****	8.30 ± 0.05****	1,702 ± 99****
6 months	8.21 ± 0.08****	1,553 ± 81****	8.19 ± 0.05	1,851 ± 49****
10 months	8.16 ± 0.06	1,484 ± 54	8.26 ± 0.05	1,876 ± 80
Indomethacin 10⁻⁵ M
3 months	7.90 ± 0.05	1,435 ± 49****	8.01 ± 0.04	1,651 ± 81****
6 months	7.58 ± 0.07^,**	1,146 ± 77**	7.73 ± 0.05^,**	1,544 ± 83
10 months	7.60 ± 0.06^,**	1,177 ± 70^,**	7.78 ± 0.04*^,**	1,582 ± 61****
l-NAME 10⁻⁴ M + indomethacin 10⁻⁵ M
3 months	8.02 ± 0.02	1,578 ± 60****	8.12 ± 0.05	1,839 ± 87^,*^,***
6 months	7.67 ± 0.03**	1,326 ± 70	7.88 ± 0.05*****	1,733 ± 58*
10 months	7.76 ± 0.04^,***	1,493 ± 77	8.00 ± 0.04*****	1,888 ± 64^,****

Values are means ± SEM. n = 10 animals per group

^*P < 0.05 vs. SAMR1 group with same age, **P < 0.05 vs. 3-month-old group of the same strain and treated group, ***P < 0.05 vs. 6-month-old group of the same strain and treated group, ****P < 0.05 vs. same age and strain of control group and *****P < 0.05 vs. same age and same strain indomethacin group