Table 3.
12-Month Functional Status Outcome | Parameter Estimate for Somatic Symptom Burden Change from Multivariable Modela | ||
---|---|---|---|
Beta | T | P | |
Sheehan Disability Index (SDI) | |||
Adjusted for covariates | .0686 | 7.13 | < .0001 |
Adjusted for covariates including depression | .0699 | 7.28 | < .0001 |
SF-12 Physical Component Summary score | |||
Adjusted for covariates | .2455 | 4.68 | < .0001 |
Adjusted for covariates including depression | .2471 | 4.71 | < .0001 |
SF-12 Mental Component Summary score | |||
Adjusted for covariates | .2343 | 3.26 | .0013 |
Adjusted for covariates including depression | .2474 | 3.50 | .0005 |
Mixed effects repeated measures multivariable models examining preceding change in somatic symptom burden as a predictor of subsequent functional status. The SDI was assessed at 4 follow-up time points (1, 3, 6, and 12 months, while the SF-12 outcomes were assessed at 2 follow-up time points (3 and 12 months). A positive coefficient means that improvement in somatic symptom burden is associated with improvement in functional status.
Covariates controlled for in models were age, sex, race, socioeconomic disadvantage index, medical comorbidity, cancer type and phase, treatment group (intervention vs. control), time in months since baseline, and baseline value of the functional status outcome being modeled. In second model, baseline HSCL-20 depression score was also added.