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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Support Care Cancer. 2012 Sep 1;21(3):765–773. doi: 10.1007/s00520-012-1578-5

Table 3.

Change in Somatic Symptom Burden as a Predictor of 12-Month Disability and Functional Status Outcomes

12-Month Functional Status Outcome Parameter Estimate for Somatic Symptom Burden Change from Multivariable Modela
Beta T P
Sheehan Disability Index (SDI)
    Adjusted for covariates .0686 7.13 < .0001
    Adjusted for covariates including depression .0699 7.28 < .0001
SF-12 Physical Component Summary score
    Adjusted for covariates .2455 4.68 < .0001
    Adjusted for covariates including depression .2471 4.71 < .0001
SF-12 Mental Component Summary score
    Adjusted for covariates .2343 3.26 .0013
    Adjusted for covariates including depression .2474 3.50 .0005
a

Mixed effects repeated measures multivariable models examining preceding change in somatic symptom burden as a predictor of subsequent functional status. The SDI was assessed at 4 follow-up time points (1, 3, 6, and 12 months, while the SF-12 outcomes were assessed at 2 follow-up time points (3 and 12 months). A positive coefficient means that improvement in somatic symptom burden is associated with improvement in functional status.

Covariates controlled for in models were age, sex, race, socioeconomic disadvantage index, medical comorbidity, cancer type and phase, treatment group (intervention vs. control), time in months since baseline, and baseline value of the functional status outcome being modeled. In second model, baseline HSCL-20 depression score was also added.