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Immunohistochemical expression of (a) NF-κB and (b) Nrf2 in adenocarcinoma cells (Experiment 1). Both proteins were expressed in the nuclei of cancer cells. The scores of immunohistochemical expression of both proteins were changed by crocin treatment: crocin feeding lowered the score for NF-κB (A) and increased it for Nrf2 (B). *P < 0.05, **P < 0.01 versus the AOM + 1.5% DSS group.
