Table 2.
BDE-47 tissue levels (ng/g tissue; ppb) of dams orally exposed to a dose of 1 mg/kg/day for 27, 54, or 70 days, corresponding to the times of breeding, parturition and weaning, respectively.
| Duration of exposure | Blood (ppb) | Brain (ppb) | Liver (ppb) | Fat (ppb) |
|---|---|---|---|---|
| Naïve (n=5)a |
2.1±1.3 | 3.3±2.2 | 2.4±0.1 | 1.4±1.1 |
| Vehicle (n=5) |
4.9±4.9 | 1.3±1.1 | 1.2±0.1 | LODb |
| 27 days (n=3) |
36.8±6.1c | 162±23c | 1510±60c | 20,800±500c |
| 54 days (n=3) |
56.9±14.4c | 306±60c | 1560±90c | 20900c,d |
| 70 days (n=7) |
9.6±3.8 | 55.2c±11.7 | 505c±115 | 6880±2090c |
a
Number of animals for each group.
b
Below limit of detection (LOD).
c
Significantly different from both Naïve and Vehicle groups (p<0.0001).
d
No SE calculated because n=2 after one outlier removed.