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. Author manuscript; available in PMC: 2013 Jan 13.
Published in final edited form as: J Neural Eng. 2012 Nov 27;9(6):065001. doi: 10.1088/1741-2560/9/6/065001

Figure 6. Tissue response measurements and histology.

Figure 6

No tissue response was observed in untreated, normal hearing cochleae (A), however a localized areolar tissue response was observed at the surgical site in deafened, SC-treated animals (arrows B,C) along with a small amount of new bone growth (arrowheads, B). The most aggressive response observed is shown in (B); mean response measured across all five treated animals was 0.5691 mm2 ± 0.0658 mm2. Importantly, only a tiny response was observed in sections adjacent to the surgical site (arrow, C). Measurements and statistical analyses of the tissue response in the treated cochleae showed a small and non-significant reaction in the lower and upper basal turns (LBT and UBT, respectively), but a significant response which was localized to the surgical site (LBT_SS; D). Scale bar in (A) 1000 μm (relative to A–C).