Figure 1.

SKA-31 transiently increases coronary flow in male and female hearts. (A and B) Simultaneous recordings of stimulus-evoked changes in coronary flow and LV developed pressure in isolated hearts from male and female rats, respectively. Changes in coronary flow were observed following acute single dose administrations of SKA-31, bradykinin (BK), and adenosine (ADO) in the amounts denoted beneath the flow tracing. Flow and pressure recordings in (A) and (B) are representative of six male and seven female heart preparations subjected to the same experimental protocol.