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. 2012 Oct 31;97(2):339–348. doi: 10.1093/cvr/cvs326

Figure 5.

Figure 5

The NO synthase inhibitor L-NNA does not impact the SKA-31-evoked increase in coronary flow. (A) Representative tracings of coronary flow (upper) and LV developed pressure (lower) in a male rat heart in response to acute administration of SKA-31 (0.5 and 5 µg), SNP (0.2 µg), bradykinin (BK, 1 µg), and adenosine (ADO, 10 µg) in the absence and continued presence of 0.1 mM L-NNA. Histograms quantifying the SKA-31, BK, ADO, and SNP evoked changes in coronary flow, LV systolic pressure, and heart rate for male and female tissues are displayed in (B)–(D), respectively. Data are given as mean ± SEM, *P < 0.05 vs. evoked response in the absence of L-NNA.