Table 5.
Incidence of malaria episodes (fever and parasitemia >2500 parasites/μl) by haemoglobin genotype and age at enrollment
| Age | Haemoglobin genotype | Number of children | Number of episodes | Incidence rate (95% CI) (per person-year) | District-adjusted rate ratio (95% CI) | P value |
|---|---|---|---|---|---|---|
| 0-1 yrs |
AA |
52 |
115 |
2.7 (2.2, 3.2) |
--- |
--- |
| |
AC |
15 |
31 |
2.5 (1.7, 3.5) |
0.93 (0.62, 1.38) |
0.72 |
| |
AS |
2 |
2 |
1.1 (0.1, 3.9) |
0.41 (0.10, 1.65) |
0.21 |
| 1-2 yrs |
AA |
66 |
131 |
2.3 (2.0, 2.8) |
--- |
--- |
| |
AC |
16 |
22 |
1.5 (1.0, 2.3) |
0.66 (0.42, 1.04) |
0.07 |
| |
AS |
9 |
19 |
2.5 (1.5, 3.9) |
0.93 (0.56, 1.54) |
0.77 |
| 2-3 yrs |
AA |
70 |
145 |
2.5 (2.1, 2.9) |
--- |
--- |
| |
AC |
10 |
8 |
0.9 (0.4, 1.7) |
0.37 (0.18, 0.75) |
0.01 |
| |
AS |
14 |
20 |
1.6 (1.0, 2.5) |
0.63 (0.40, 1.01) |
0.06 |
| 3-4 yrs |
AA |
77 |
95 |
1.4 (1.1, 1.7) |
--- |
--- |
| |
AC |
17 |
32 |
2.2 (1.5, 3.1) |
1.61 (1.08, 2.41) |
0.02 |
| |
AS |
6 |
9 |
1.7 (0.8, 3.2) |
1.05 (0.53, 2.09) |
0.89 |
| 4-5 yrs |
AA |
66 |
56 |
0.9 (0.7, 1.2) |
--- |
--- |
| |
AC |
10 |
11 |
1.2 (0.6, 2.2) |
1.27 (0.66, 2.44) |
0.48 |
| AS | 6 | 0 | 0.0 (0.0, 0.6) | 0.00 | 1.00 |