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. 2013 Jan 2;33(1):26–34. doi: 10.1523/JNEUROSCI.4147-12.2013

Figure 3.

Figure 3.

Summary of the effects of MK-801 treatment administered during adulthood. a, Diagram illustrating the experimental design. Five noncontingent injections of saline (n = 8) or MK-801 (n = 8) were performed in adult rats, and changes in prefrontal LFP response to ventral hippocampal train stimulation were assessed within the P105–P125 age period. Bottom shows the location of all recording and stimulation sites determined by means of histological analyses from Nissl-stained sections. b, Similar to the adolescent-treated groups, vehicle and MK-801 treatment in adulthood did not alter the characteristic prefrontal LFP facilitation induced by hippocampal stimulation at 10 Hz (main effect of pulse number, F(9,140) = 5.12, ***p < 0.0005, two-way ANOVA). c, At 20 Hz, a transient LFP inhibition was observed in the PFC of both saline- and MK-801-treated rats (main effect of pulse number, F(9,150) = 2.70, *p < 0.05, two-way ANOVA). d, Similarly, the magnitude of prefrontal LFP inhibition observed after ventral hippocampal train stimulation at 40 Hz remained intact when MK-801 exposure occurred in adulthood (main effect of pulse number, F(9,150) = 120.74, ***p < 0.0005, two-way ANOVA). PD, Postnatal day.