Comparison of PBL mutant frequencies from normal controls and MSI-H HNPCC patients (by age in years). The squares represent the normal controls used in this study, and those from our previously published aging study (MAD 126:1051, 2005). The circles represent the MSI-H HNPCC patient PBL DNAs used in this study and the patient previously published, (Genomics 84:419, 2004.) The lower line on the graph is the linear regression line for the normal controls. Its equation is the bottom one in the upper left corner. The top equation is for the upper linear regression line for the MSI-H patients, circles. The numbers associated with the circles are the patient IDs.