Pairwise comparisons of nonneoplastic mucosa with low-grade dysplasia in adenoma (NM:ALG), with high-grade dysplasia in adenoma (NM:AHG), and with adenocarcinoma (NM:CA); and between low-grade 2 or high-grade dysplasia and adenocarcinoma (ALG:CA and AHG:CA, respectively). Each row represents the P values for each pairwise comparison for the miRNA listed in the right column 1. The type 1 pattern is 1 defined by miRNAs that are altered between mucosa and low-grade dysplasia and includes 3 subtypes of miRNAs with early persistent (1A), early intermittent (1B), and early transient (1C) alterations. The type 2 pattern is evident for miRNAs that are not altered in expression between mucosa and low-grade dysplasia but are altered late in the NM-A-AC sequence. MiRNAs with late intermediate (2A) and late (2B) alterations are illustrated.