Table 1.
Summary of identified miR targets in the Wnt signaling pathway illustrating redundant relationships in the functional pathway components.
| Designation | Frizzled | Ebil | CBP | NLK | CycD | Prickle | PLC | CaMKII | NFAT |
|---|---|---|---|---|---|---|---|---|---|
| Pathway | Can., PCP, Ca++ | Canonical | PCP | Calcium Ion | |||||
| miR | |||||||||
| −20a | + | + | + | + | + | ||||
| −23a | + | + | |||||||
| −25 | + | + | + | ||||||
| −27a | + | + | + | + | |||||
| −34a | + | + | + | ||||||
| −92a | + | + | + | + | + | + | |||
| −148a | + | + | + | + | + | + | |||
| −203 | + | + | + | + | |||||
| Designation | Gene Symbol | Name |
|---|---|---|
| Frizzled | FZD4 | frizzled homolog 4 (Drosophila) |
| FZD7 | frizzled homolog 7 (Drosophila) | |
| Ebil | TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 |
| CBP | EP300 | E1A binding protein p300 |
| NLK | NLK | nemo-like kinase |
| CycD | CCND1 | cyclin D1 |
| Prickle | PRICKLE2 | prickle homolog 2 (Drosophila) |
| PLC | PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) |
| CaMKII | CAMK2A | calcium/calmodulin-dependent protein kinase II alpha |
| NFAT | NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive |
Can. = Canonical pathway; PCP = Planar polarity pathway; Ca++ = Calcium ion pathway