Histopathology in synchronous CRCs with/without CIMP. A, B, and C, cribriform glandular architecture as follows: a gland with a comedo-like pattern and bridging of cells across the lumen has spaces filled with necrotic debris. These tumors (A, B, and C) showed CIMP, whereas a tumor without cribriform glandular architecture did not (D). A and B, histologic findings of a patient with two proximal CRCs; C and D, histologic findings in a patient with a proximal and a distal CRC, respectively.