Table 3.
Reclassification using the Pepe method for major osteoporotic fracture and hip fracture using the National Osteoporosis Foundation threshold for treatment
| Major osteoporotic fracture:10-year risk FRAX with FN BMD | ||||||
|---|---|---|---|---|---|---|
| Cases (n=1037) | Non-cases (n=4999) | |||||
| 10-year risk from model with FN BMD and age | <20% | ≥20% | Total | <20% | ≥20% | Total |
| <20% | 362 | 79 | 441 | 3086 | 346 | 3432 |
| ≥20% | 149 | 447 | 596 | 631 | 936 | 1567 |
| Total | 511 | 526 | 1037 | 3717 | 1282 | 4999 |
| Hip fracture: 10-year risk FRAX with FN BMD | ||||||
| Cases (n=389) | Non-cases (n=5765) | |||||
| 10-year risk from model with FN BMD and age | <3% | ≥3% | Total | <3% | ≥3% | Total |
| <3% | 29 | 3 | 32 | 1925 | 83 | 2008 |
| ≥3% | 34 | 323 | 357 | 1115 | 2720 | 3835 |
| Total | 63 | 326 | 389 | 3040 | 2803 | 5843 |
Net Reclassification Index (NRI) major osteoporotic fracture= (79/1037-149/1037)- (346/4999-631/4999)= −1.0%
NRI hip fracture= (3/389-34/389)-(83/5843-1115/5843)=9.7%