Table 4.
Reclassification using Cook method of major osteoporotic fractures and hip fracture using NOF threshold for treatment
| Major osteoporotic fracture: 10-year risk from FRAX with FN BMD |
|||||
|---|---|---|---|---|---|
| 10-year risk from model with FN BMD and age |
<20% | ≥ 20% | Total | ||
| <20% | |||||
| Women, n | 3448 | 425 | 3873 | ||
| Events, n | 362 | 79 | 441 | ||
| Observed 10-year fracture rate, % | 11.6 | 21.2 | 12.6 | ||
| ≥ 20% | |||||
| Women, n | 780 | 1383 | 2163 | ||
| Events, n | 149 | 447 | 596 | ||
| Observed 10-year fracture rate, % | 22.6 | 42.1 | 34.6 | ||
| Total | |||||
| Women, n | 4228 | 1808 | 6036 | ||
| Events, n | 511 | 526 | 1037 | ||
| Observed 10-year fracture rate, % | 13.5 | 36.7 | 19.8 | ||
|
Hip fracture: 10-year risk from FRAX with FN BMD |
|||||
|
10-year risk from model with FN BMD and age |
<3% | ≥ 3% | Total | ||
| <3% | |||||
| Women, n | 1954 | 86 | 2040 | ||
| Events, n | 29 | 3 | 32 | ||
| Observed 10-year fracture rate, % | 1.5 | 3.8 | 1.6 | ||
| ≥3% | |||||
| Women, n | 1149 | 3043 | 4192 | ||
| Events, n | 34 | 323 | 357 | ||
| Observed 10-year fracture rate, % | 3.1 | 12.0 | 9.4 | ||
| Total | |||||
| Women, n | 3103 | 3129 | 6232 | ||
| Events, n | 63 | 326 | 389 | ||
| Observed 10-year fracture rate, % | 2.1 | 11.7 | 6.8 | ||