Figure 3.

P2X7 receptor and status epilepticus. A. Representative EEG spectrograms showing frequency and amplitude data during kainate-induced status epilepticus for a wild-type (WT) mouse and a mouse lacking the P2X7 receptor (P2rx7-/-). B. Representative EEG spectrograms during recordings after triggering status epilepticus for vehicle (veh) and P2X7 receptor antagonist (A-438079 (A-43), 1.75 nmol) injected mice. Note, reduced seizure severity in P2rx7-/- and A43-treated mice. C. Representative EEG trace recordings from mice after triggering status epilepticus. Time markings on left of each panel refer to point when either Veh, lorazepam or A43 were injected 60 min post-status epilepticus (when seizures are normally continuous). Lorazepam partly reduces seizures but does not abolish them whereas the combination of lorazepam and A43 results in full seizure termination. Data are adapted and reproduced with permission from Engel et al. FASEB J. [62].