Table 2. Regional Brain Uptake (In Standard Uptake Values) of [11C-Carbonyl]aryl Carbamates at 2 and 40 min Post iv Injection in Rat.
| compd no | cortex (2 min) | hypothalamus (2 min) | cortex (40 min) | hypothalamus (40 min) | cortex (40 min, blocked)a |
|---|---|---|---|---|---|
| [11C]1 | 2.40 ± 0.18 | 1.61 ± 0.23 | 2.49 ± 0.25 | 1.14 ± 0.13 | 0.36 ± 0.04b |
| [11C]2 | 0.79 ± 0.04 | 0.47 ± 0.03 | 0.94 ± 0.11 | 0.51 ± 0.10 | 0.17 ± 0.04b |
| [11C]3 | 2.36 ± 0.13 | 1.87 ± 0.08 | 3.09 ± 0.24 | 1.22 ± 0.15 | 0.33 ± 0.05b |
| [11C]4 | 2.68 ± 0.26 | 1.81 ± 0.29 | 3.37 ± 0.07 | 1.48 ± 0.08 | 0.23 ± 0.05b |
| [11C]5 | 1.63 ± 0.09 | 1.21 ± 0.07 | 2.49 ± 0.15 | 1.25 ± 0.04 | 0.27 ± 0.03b |
| [11C]6 | 4.52 ± 0.32 | 2.10 ± 0.17 | 6.61 ± 0.67 | 2.19 ± 0.10 | 0.74 ± 0.41b |
| [11C]7 | 3.00 ± 0.12 | 1.44 ± 0.07 | 4.05 ± 0.38 | 1.43 ± 0.08 | 0.17 ± 0.02b |
| [11C]8 | 3.58 ± 0.04 | 2.19 ± 0.14 | 5.30 ± 0.20 | 2.88 ± 0.13 | 0.20 ± 0.03b |
a
Pretreated with compound 2 (2 mg/kg, ip).
b
Significantly different from controls (p < 0.01). Each value represents the mean (n = 5) ± SD.