Table 2.
Incidence of Hyperkalemia (per 100 patient-months) among patients with and without CKD and/or Renin Angiotensin AldosteroneSystem (RAAS) blocker treatment
| Potassium ≥ 5.5 mg/dl (inclusive) |
Potassium ≥5.5 and <6.0 mg/dl |
Potassium ≥ 6.0 mg/dl |
||
|---|---|---|---|---|
| Total Number of Potassium Events | 66259 | 44907 | 21352 | |
| Total Number of Patient Months | 1581299 | 1581299 | 1581299 | |
| RAAS Blocker Treatment | ||||
| CKD | ||||
| Number of events | 29023 | 19371 | 9652 | |
| Number of Patient Months | 317701 | 317701 | 317701 | |
| Adjusted Rate1,2 | 7.67 (7.57, 7.78) | 5.06 (4.97, 5.14) | 2.60 (2.54, 2.66) | |
| NO CKD | ||||
| Number of events | 15302 | 10714 | 4588 | |
| Number of Patient Months | 577747 | 577747 | 577747 | |
| Adjusted Rate1,2 | 2.30 (2.26, 2.33) | 1.63 (1.59, 1.66) | 0.67 (0.65, 0.69) | |
| No RAAS Blocker Treatment | ||||
| CKD | ||||
| Number of events | 12709 | 8506 | 4203 | |
| Number of Patient Months | 146884 | 146884 | 146884 | |
| Adjusted Rate1,2 | 8.22 (8.07, 8.37) | 5.43 (5.31, 5.56) | 2.76 (2.68, 2.85) | |
| NO CKD | ||||
| Number of events | 9225 | 6316 | 2909 | |
| Number of Patient Months | 538967 | 538967 | 538967 | |
| Adjusted Rate1,2 | 1.77 (1.73, 1.81) | 1.24 (1.21, 1.27) | 0.53 (0.51, 0.55) | |
1.
Adjusted rates are per 100 patient months, all p-values<0.0001, (95%CI)
2.
Adjusted for confounders: race, gender, age, CCI, cancer, diabetes, CVD, and RAAS blocker treatment within 30 days