Table 1.
Solubility of pranlukast hemihydrate in various oils and surfactants at 30°C
| Vehicle | Solubility (mg/g) |
|---|---|
| Oils | |
| Glyceryl triacetate | 0.10 ± 0.00 |
| Isopropyl myristate | 0.11 ± 0.00 |
| Triethyl citrate | 0.50 ± 0.01 |
| Propylene glycol | 0.50 ± 0.02 |
| Labrafil M 1944 CS® | 0.93 ± 0.02 |
| PEG 400 | 2.15 ± 0.01 |
| Lauroglycol FCC® | 3.24 ± 0.06 |
| Triethanolamine | 3.97 ± 0.20 |
| Benzyl alcohol | 5.84 ± 0.08 |
| Surfactants/cosurfactants | |
| Span 20 | 0.66 ± 0.01 |
| Labrasol® | 2.22 ± 1.64 |
| Tween 80 | 2.66 ± 0.38 |
| Transcutol P® | 2.96 ± 0.02 |
| Cremophor EL® | 3.58 ± 0.04 |
| Tween 20 | 7.76 ± 0.35 |
Note: Each value represents the mean ± SD (n = 3).
Abbreviation: PEG, polyethylene glycol.