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Saturated solubility of pranlukast from 3% pranlukast hemihydrate-loaded SMEDDS in aqueous media
| Formulation | Solubility (mg/ml) | |||
|---|---|---|---|---|
|
|
||||
| Water | pH 1.2 | pH 4.0 | pH 6.8 | |
| Powder | 0.01 ± 0.00 | 0.00 ± 0.00 | 0.01 ± 0.00 | 0.01 ± 0.00 |
| A | 4.73 ± 0.16 | 0.09 ± 0.00 | 4.95 ± 0.10 | 6.07 ± 0.08 |
| B | 5.72 ± 0.17 | 3.60 ± 0.18 | 4.93 ± 0.22 | 4.26 ± 0.01 |
| C | 5.00 ± 0.08 | 0.08 ± 0.00 | 5.04 ± 0.06 | 5.44 ± 0.15 |
Note: Each value represents the mean ± SD (n = 3).
Abbreviation: SMEDDS, self-microemulsifying drug delivery system.
