Table 7.
Pharmacokinetic parameters after oral administration of SMEDDS and an aqueous suspension at a dose of 40 mg/kg
| PLH-loaded SMEDDS | PLH aqueous suspension | |
|---|---|---|
| Cmax (ng/mL) | 384.3 ± 61.8 | 105.2 ± 9.6 |
| Tmax (h) | 4.7 ± 3.0 | 5.0 ± 3.6 |
| AUClast (ng · h/mL) | 2855.3 ± 1129.9 | 967.5 ± 441.4 |
| MRTlast (h) | 5.1 ± 1.8 | 5.6 ± 2.4 |
Note: Each value represents the mean ± SD (n = 3).
Abbreviations: AUC, area under the curve; Cmax, peak plasma concentration; MRTlast, mean residence time; PLH, pranlukast hemihydrate; SMEDDS, self-microemulsifying drug delivery system; Tmax, the time to reach Cmax.