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. Author manuscript; available in PMC: 2013 Jan 14.
Published in final edited form as: Lung Cancer. 2009 Jan 31;66(1):58–63. doi: 10.1016/j.lungcan.2009.01.004

Fig.1.

Fig.1

Genetic analysis of exfoliated cells from sputum by the mini-chip for genomic copy changes of HYLA2, FHIT, p16, and SP-A. A, bronchial epithelial cells enriched from sputum of a healthy control shows two green signals of the HYAL2 probe (thick solid green arrow), two yellow signals from the FHIT probe (thick solid yellow arrow), and two red signals of the CEP3 probe (thin red arrow) that is used as internal control for assessing changes of the genetic targets. B, bronchial epithelium obtained from a lung cancer patient shows hemizygous deletions of HYAL2 or FHIT (one green or yellow signal, two red spots) or homozygous deletion of HYAL2 or FHIT (no green or yellow signal, two red signals). C, sputum from a healthy individual shows two green signals from the SP-A probe (thick solid green arrow) and two red spots from the CEP10 probe (thin red arrow). D, bronchial epithelium obtained from a lung cancer patient shows homozygous deletion of SP-A (no green signal and two red signals) and hemizygous deletion of SP-A (one green signal and two red signals). Original magnification, ×400.