Figure 2.

a) Coordination features of the primary solution Cu²⁺ site of α-syn. Competition studies show that this complex exhibits a dissociation constant of approximately 0.1 nM. b) α-Syn in its helical form, resulting from membrane association, would result in a separation of His50 from the N-terminus of approximately 75Å. Consequently, Cu²⁺ coordination details must be altered relative to that in solution.