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. Author manuscript; available in PMC: 2013 Jan 14.
Published in final edited form as: Alcohol Clin Exp Res. 2011 Jan 11;35(4):671–688. doi: 10.1111/j.1530-0277.2010.01385.x

Figure 7.

Figure 7

Adolescent ethanol binge causes a reduction in the volume of the olfactory bulb in adults. Adolescent mice received either water or ethanol (5g/kg) once a day for ten days (P28-37). Postmortem MRI was performed on adults (P79). Following automatic segmentation, manual segmentation of the olfactory was performed by blinded investigators. (A) 3D representation of the brain showing large relative size of the olfactory bulb in the rodent brain (darkened). (B) Overlay of 3D renderings of representative control and ethanol treated adult olfactory bulbs. Arrowheads highlight volume differences between control (black) and ethanol treated (white) groups (C) Adult olfactory bulb volume quantification following manual correction. Adult mice that received binge ethanol treatment during adolescence showed a 7.8% reduction in the olfactory bulb volume (Control: 23.37 ± 0.42 mm3; Ethanol: 21.54 ± 0.33 mm3; **p<0.005; N=10 Control, 8 Ethanol).