Skip to main content
. Author manuscript; available in PMC: 2013 Jan 14.
Published in final edited form as: Alcohol Clin Exp Res. 2011 Jan 11;35(4):671–688. doi: 10.1111/j.1530-0277.2010.01385.x

Table 2.

The effect of adult binge ethanol on neurotransmitter receptor and regulator gene expression.

Symbol Description P88 Control P98 (Adult Ethanol) P148 Control P148 (Adult Ethanol)
Peptide receptors
Cckar Cholecystokinin α receptor 100 108 66 44*
Galr1 Galanin receptor 1 100 45 33* 43
Galr2 Galanin receptor 2 100 79 111 45*
Npffr2 Neuropeptide FF receptor 2 100 70 21*§ 36
Npy2r Neuropeptide Y receptor Y2 100 94 33* 65
Npy5r Neuropeptide Y receptor Y5 100 89 39* 80
Prokr2 Prokineticin receptor 2 100 87 24*§ 47
Tacr3 Tachykinin receptor 3 100 54 31* 51
Cholinergic receptors
Chrm3 Cholinergic receptor, muscarinic 3 100 88 33* 57
Chrm4 Cholinergic receptor, muscarinic 4 100 83 38* 79
Chrm5 Cholinergic receptor, muscarinic 5 100 81 31* 58
GABA receptors
Gabra4 GABA-A receptor, α4 100 71 25*§ 60
Gabrr2 GABA-A receptor, ρ2 100 111 65 87
Gad1 Glutamic acid decarboxylase 1 100 70 21*§ 51

Adult alcohol binge slightly alters neurotransmitter gene expression across development. Mice received either water or ethanol (5g/kg) once a day for 10 days during adulthood (P88-97). The expression of 84 neurotransmitter receptor genes was assessed in whole brain either 24 hours after treatment (P98; N=6 Control, 6 Ethanol) or in adulthood (P148; N=5 Control, 6 Ethanol) using an RT2 Profiler Neurotransmitter Receptor and Regulator Superarray™. Gene expression levels are given as the percent of P88 control. Genes that changed in at least one treatment group are presented. A 2-way ANOVA with Bonferroni post-tests to account for multiple comparisons was used to determine statistical significance of individual genes (§ p<0.05). Student t-tests were also performed in order to gain insight into other genes that might be changing, however t-test analysis may produce type II errors.(t-test versus P88 control:

*

p<0.05).