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Effect of A1120 on isomerohydrolase activity in bovine RPE microsomes. Bovine RPE microsomes (30 μg of protein) were incubated with DMSO (A) or 200 μM A1120 (B) in the presence of all-trans 3H-retinol (0.2 μM) for 2 hours. The generated retinoids were analyzed by HPLC with peak 1 representing retinyl ester, peak 2 representing all-trans retinol, peak 3 representing 11-cis retinol, and peak 4 representing all-trans retinol.
