Figure 2.

Relationship between levels of TRF1 and TRF2 protein and telomere DNA content (TC). TC was compared with protein levels of TRF1 and TRF2 measured by Western blot in 36 human breast tumors. Lines on each graph were fit using simple linear regression, and statistical analysis was done to determine the significance (P-value), coefficient of determination (r²), and the correlation coefficient (r). (a) TRF1 protein level compared with TC, this graph shows a significant increase in TRF1 protein levels with decreased TC (P = 0.013). (b) TRF2 protein level compared with TC, this graph shows the trend for increased TRF2 protein levels with decreased TC (P = 0.063).