Table 1.

HER2 Hazard Ratios by HR Status and Site of Recurrence

Site	HR Negative Patients	HR Positive Patients	p-value*
Brain	1.40 (1.00, 1.70)	2.88 (2.24, 3.71)	<0.0001
Liver	1.10 (0.89, 1.40)	1.50 (1.22, 1.84)	0.31
Lung	0.72 (0.58, 0.90)	1.43 (1.12, 1.83)	<0.0001
Pleura	0.62 (0.43, 0.88)	1.08 (0.76, 1.53)	0.027
Bone	0.72 (0.56, 0.92)	1.11 (0.92, 1.33)	0.0056
Dist LN**	0.63 (0.48, 0.83)	1.29 (1.00, 1.67)	0.0002

^*p-value tests whether the effect of HER2 status varied significantly with HR status

^**Dist LN = distant lymph node

Numbers in parentheses are 95% confidence intervals for the hazard ratios.