Fig. 1.

Kinetics of plasma Hcy-thiolactone and total Hcy in mice. Representative kinetics of Hcy-thiolactone (A) and tHcy (B) turnover obtained for individual Pon1^−/− (○) and Pon1^+/+(x) mice injected intraperitoneally with 600 nmol L-Hcy-thiolactone/g body weight are shown. Data points were fitted to the exponential equation [A^t] = [A⁰]· e^−k·t, where k is a first order rate constant, [A^t] and [A⁰] are measured concentrations at time t and extrapolated concentrations at time zero, respectively.