Table 2.

Urinary Hcy-thiolactone and total Hcy output in Pon1^−/− and wild type mice. The mice were fed with a 1% Met-supplemented drinking water for 8 weeks. Consumption of Met-supplemented water (3.1 mL/ mouse) was not affected by the genotype

Genotype (n)	Urinary Hcy-thiolactone, nmol/24 h	Urinary tHcy, nmol/24 h	Urine volume, mL/24 h	Mouse body weight, g
Pon1−l− (4)	3.2 ± 0.5*	1004 ± 207	1.24 ± 0.19*	23.4 ± 1.4
Wild type (9)	1.3 ± 0.4	817±231	0.58 ± 0.14	21.4 ± 0.7

^*Significantly increased versus wild type: p < 0.001.