. Author manuscript; available in PMC: 2013 Jan 14.

Published in final edited form as: J Alzheimers Dis. 2012;30(2):225–231. doi: 10.3233/JAD-2012-111940

Table 3.

Turnover of Hcy-thiolactone and total Hcy in mouse blood in vivo. L-Hcy-thiolactone was injected i.p. (600nmol/g body weight). Half-lives (t_0.5 = 0.69/k) and plasma concentrations at time zero (HTL ⁰, tHcy⁰) were calculated from the plasma concentrations at time t (HTL^t, tHcy^t) according to the equation [HTL^t] = [HTL⁰]·e^−k·t or [tHcy^t ]= [tHcy⁰ ] ·e^−k·t , where k is a first order rate constant

Genotype	Diet	HTL⁰, μM	HTL t_0.5, min (n)	tHcy⁰, μM	tHcy t_0.5, min (n)
Pon1 ^−/−	Control	34.1 ± 9.5	5.9 ± 1.2(6)	256 ± 23	27.1 ± 6.3 (4)
Wild type	Control	39.0 ± 13.9	5.0 ± 0.9 (15)	524±136	26.2 ± 2.6 (5)