Table 4.

Pon1 protects against Hcy-thiolactone neurotoxicity in mice. L-Hcy-thiolactone was injected i.p. (3,700 nmol/g body weight) and the mice were monitored for 90 min

Genotype (n)	Incidence of seizures, % (n)	Incidence of death, %	Seizure latency period, min	Death latency period, min
Pon1−/− (36)	52.8 (19)*	8.3 (3)	31.8±11.6‡	50±30
Wild type (44)	29.5 (13)	2.3 (1)	41.2±10.8	61

^*Significantly different from wild type – Fisher exact test p = 0.042 versus wild type

^‡T-test p = 0.019 versus wild type.