Fig. 6.

A: key transcripts in MECH model family. Transcripts with bold and italic font have higher z-scores in skeletal muscle than in other tissues (P < 0.05). See Fig. 5A legend for color-coding scheme. B: structural protein connectivity of the five subgroups composing the MECH model family. Connections ending with solid circle represent mechanical bonding. The “*” at the end of some proteins' names indicates that the protein has different isoforms in different types of fibers. Actin subfamily includes proteins associated mainly with the thin filament. Myosin subfamily includes proteins associated mainly with the thick filament. Z-disk subfamily includes proteins localized at the Z-disk and some intermediate filament proteins also associated with costameres. TransMem subfamily includes transmembrane “scaffolding” proteins just internal to or crossing the sarcolemma. ECM subfamily includes proteins composing the extracellular matrix for muscle tissue. See text and supplemental tables for definitions of acronyms.