Fig. 8.

Signaling proteins involved in skeletal muscle remodeling processes. The green nodes are proteins in SIGP family, the red nodes are other protein families, and the blue nodes are key dynamic states in the final muscle model framework. Along the bottom are functional consequences related to phenotypic remodeling of skeletal muscle, including changes in the mass/size (atrophy and hypertrophy), fiber composition (percentage of slow type I and fast type II fibers), and fatigue resistance (proportion of oxidative vs. glycolytic fibers, and volume of mitochondria). See text and supplemental tables for definitions of acronyms.