Table 1.
Samplea | status | n | % male [%] | age [mean ± SD] | BMI [mean ± SD] | BMI SDSb[mean ± SD] |
---|---|---|---|---|---|---|
Mutation Screen |
Cases |
95 |
48.42 |
13.43 ± 3.37 |
31.87 ± 5.04 |
4.10 ± 1.71 |
SI: family-based GWAS |
Cases |
705 |
45.11 |
13.44 ± 3.02 |
32.02 ± 5.82 |
4.23 ± 1.96 |
|
Parents |
1,410 |
50.00 |
42.54 ± 6.02 |
30.28 ± 6.33 |
1.65 ± 1.84 |
SII: case–control GWAS |
Cases |
453 |
42.60 |
14.37 ± 3.75 |
33.15 ± 6.68 |
4.51 ± 2.15 |
|
Controls |
435 |
39.08 |
26.08 ± 5.75 |
18.09 ± 1.14 |
−1.45 ± 0.34 |
SIII: subset of case–control GWAS (for association testing) |
Cases |
179 |
49.16 |
14.27 ± 2.39 |
35.56 ± 6.13 |
5.3 ± 2.09 |
Controls |
185 |
55.68 |
25.56 ± 3.94 |
18.39 ± 1.09 |
−1.47 ± 0.33 |
|
SIV: obese adults |
Cases |
988 |
37.25 |
47.17 ± 14.23 |
35.70 ± 5.43 |
3.22 ± 1.66 |
SV: DAPOC |
Cases |
1,185 |
44.22 |
10.72 ± 2.78 |
27.69 ± 5.11 |
3.07 ± 1.56 |
SVI: KORA |
Cases |
6.633 |
56,43 |
56.62 ± 13.13 |
29.42 ± 3.70 |
1.19 ± 1.09 |
|
Controls |
3.444 |
36,76 |
47.18 ± 13.37 |
22.72 ± 1.68 |
−0.53 ± 0.51 |
SVII: Ulm children’s study 1 |
Cases |
97 |
57.73 |
7.57 ± 0.42 |
20.68 ± 1.71 |
1.06 ± 0.46 |
|
Controls |
685 |
54.31 |
7.56 ± 0.42 |
15.63 ± 1.38 |
−0.25 ± 0.37 |
SVIII: BEPOC |
Cases |
1,046 |
47.99 |
10.89 ± 3.57 |
29.46 ± 5.91 |
3.54 ± 1.82 |
SIX: Ulm children’s study 2 |
Cases |
271 |
51.29 |
11.07 ± 3.69 |
29.75 ± 6.04 |
3.62 ± 1.88 |
SX: Ulm children’s study 3 | Cases | 129 | 43.41 | 14.90 ± 1.84 | 40.45 ± 8.00 | 7.05 ± 2.92 |
aMutation Screen sample: part of the family-based and the case–control GWAS samples’ cases; Family-based GWAS sample: 705 index patients with early-onset extreme obesity and their biological parent; case–control GWAS sample: GWAS of early-onset extremely obese children and adolescents in comparison to lean, adult controls; case–control sample for association testing: early-onset extremely obese children and adolescents in comparison to lean, adult controls; independent of initial screening sample; subset of cases-control GWAS sample; DAPOC: Datteln Paediatric Obese Cohort (27); KORA: Cooperative Health Research in the Region of Augsburg (30); Ulm children’s study 1: Ulm Research on Metabolism, Exercise and Lifestyle in Children (31); BEPOC: Berlin Paediatric Obese Cohort (28); Ulm children’s study 2 and 3: Ulm Paediatric Obese Cohort A and B (INSULA) (29).
bCalculation of the BMI SDS values has been based on population reference values following the National Nutrition Survey I (25).