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. 2012 Dec 27;5:65. doi: 10.1186/1755-8794-5-65

Table 1.

Phenotypic description of analyzed study groups

Samplea status n % male [%] age [mean ± SD] BMI [mean ± SD] BMI SDSb[mean ± SD]
Mutation Screen
 Cases
 95
 48.42
 13.43 ± 3.37
 31.87 ± 5.04
 4.10 ± 1.71
SI: family-based GWAS
 Cases
 705
 45.11
 13.44 ± 3.02
 32.02 ± 5.82
 4.23 ± 1.96
 
 Parents
 1,410
 50.00
 42.54 ± 6.02
 30.28 ± 6.33
 1.65 ± 1.84
SII: case–control GWAS
 Cases
 453
 42.60
 14.37 ± 3.75
 33.15 ± 6.68
 4.51 ± 2.15
 
 Controls
 435
 39.08
 26.08 ± 5.75
 18.09 ± 1.14
 −1.45 ± 0.34
SIII: subset of case–control GWAS  (for association testing)
 Cases
 179
 49.16
 14.27 ± 2.39
 35.56 ± 6.13
 5.3 ± 2.09
Controls
 185
 55.68
 25.56 ± 3.94
 18.39 ± 1.09
 −1.47 ± 0.33
SIV: obese adults
 Cases
 988
 37.25
 47.17 ± 14.23
 35.70 ± 5.43
 3.22 ± 1.66
SV: DAPOC
 Cases
 1,185
 44.22
 10.72 ± 2.78
 27.69 ± 5.11
 3.07 ± 1.56
SVI: KORA
 Cases
 6.633
 56,43
 56.62 ± 13.13
 29.42 ± 3.70
 1.19 ± 1.09
 
 Controls
 3.444
 36,76
 47.18 ± 13.37
 22.72 ± 1.68
 −0.53 ± 0.51
SVII: Ulm children’s study 1
 Cases
 97
 57.73
 7.57 ± 0.42
 20.68 ± 1.71
 1.06 ± 0.46
 
 Controls
 685
 54.31
 7.56 ± 0.42
 15.63 ± 1.38
 −0.25 ± 0.37
SVIII: BEPOC
 Cases
 1,046
 47.99
 10.89 ± 3.57
 29.46 ± 5.91
 3.54 ± 1.82
SIX: Ulm children’s study 2
 Cases
 271
 51.29
 11.07 ± 3.69
 29.75 ± 6.04
 3.62 ± 1.88
SX: Ulm children’s study 3 Cases 129 43.41 14.90 ± 1.84 40.45 ± 8.00 7.05 ± 2.92

aMutation Screen sample: part of the family-based and the case–control GWAS samples’ cases; Family-based GWAS sample: 705 index patients with early-onset extreme obesity and their biological parent; case–control GWAS sample: GWAS of early-onset extremely obese children and adolescents in comparison to lean, adult controls; case–control sample for association testing: early-onset extremely obese children and adolescents in comparison to lean, adult controls; independent of initial screening sample; subset of cases-control GWAS sample; DAPOC: Datteln Paediatric Obese Cohort (27); KORA: Cooperative Health Research in the Region of Augsburg (30); Ulm children’s study 1: Ulm Research on Metabolism, Exercise and Lifestyle in Children (31); BEPOC: Berlin Paediatric Obese Cohort (28); Ulm children’s study 2 and 3: Ulm Paediatric Obese Cohort A and B (INSULA) (29).

bCalculation of the BMI SDS values has been based on population reference values following the National Nutrition Survey I (25).